Stage 4 colon cancer is the most advanced phase of the disease, where cancer cells have already spread (metastasized) to other organs or areas of the body. One of the most common sites of spread is the abdominal cavity, a condition known as peritoneal metastasis. In cases like this, one of the treatment options that may be considered is the CRS-HIPEC procedure— a combination of cytoreductive surgery to remove visible tumors followed by heated chemotherapy delivered directly into the abdominal cavity to target any remaining cancer cells.
Mandaya Royal Puri Hospital provides CRS-HIPEC treatment performed by experienced digestive surgery specialists. Supported by advanced technology and a highly skilled medical team, the hospital offers a comprehensive treatment option for stage 4 colon cancer patients who require a specialized therapeutic approach.
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Understanding CRS-HIPEC Chemotherapy for Stage 4 Colon Cancer Treatment
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a cancer treatment method used for cancers that have spread to the lining of the abdominal cavity (peritoneum). HIPEC is typically performed together with cytoreductive surgery (CRS), a procedure in which surgeons remove as much visible tumor as possible inside the abdomen.
After the surgical removal of tumors, the abdominal cavity is then infused with heated chemotherapy to destroy microscopic cancer cells that may remain. This combined approach is commonly referred to as HIPEC surgery. The method can help reduce the risk of cancer recurrence, extend survival, and in some cases even offer a chance of recovery—especially for patients undergoing stage 4 cancer treatment involving peritoneal spread.
During HIPEC, chemotherapy is heated to around 41–43°C. This is why the procedure is sometimes known as “heated chemotherapy” or “hot chemotherapy wash.” Warming the solution helps it penetrate tissues more effectively, enhancing its ability to kill cancer cells.
Unlike standard chemotherapy that circulates throughout the entire body, HIPEC works locally—targeting the exact area where the cancer has spread. This allows for a higher concentration of chemotherapy at the cancer site while reducing systemic side effects because only a small amount of the drug enters the bloodstream.
Benefits of CRS-HIPEC for Stage 4 Colon Cancer That Has Spread to the Abdomen
CRS-HIPEC is considered one of the more effective stage 4 colon cancer treatment options for patients whose cancer has spread to the peritoneum. Here are some of its key benefits:
1. Reaches areas that standard chemotherapy cannot
Systemic chemotherapy often cannot effectively reach the peritoneal lining, leaving certain areas untreated. CRS-HIPEC delivers the chemotherapy directly into the abdominal cavity so that previously hard-to-reach cancer cells can be targeted more precisely.
2. More effective in killing cancer cells at the metastasis site
Since the chemotherapy is administered exactly where the cancer has spread, CRS-HIPEC can destroy cancer cells—including microscopic ones—more accurately after the main tumor has been surgically removed.
3. Higher dosage and stronger effect through heated chemotherapy
The chemotherapy solution is heated to about 40–50°C before being circulated inside the abdomen. The warmth improves tissue absorption and enhances the cancer-killing effect, potentially providing better outcomes than conventional chemotherapy.
4. Performed in one single operative session
Unlike regular chemotherapy that requires multiple cycles over weeks or months, CRS-HIPEC is performed once during surgery. After the main tumor is removed, the heated chemotherapy is circulated in the abdomen for 30–90 minutes, offering a more efficient treatment process.
5. Fewer side effects
Because the drug acts locally in the abdomen and only a small amount enters the bloodstream, side effects such as severe nausea, hair loss, or organ toxicity tend to be milder. This allows patients to recover more comfortably and more quickly.
6. A modern treatment option for advanced-stage cancer
CRS-HIPEC is considered a breakthrough for stage 4 cancer treatment, particularly for colon cancer that has metastasized to the peritoneum. The procedure can help reduce recurrence and improve the overall success rate of therapy.
Colon Cancer Specialists at Mandaya Royal Puri Hospital
Here are the digestive surgery specialists who treat colon cancer at Mandaya Royal Puri Hospital:
1. dr. Ocsyavina, Sp.B, Subsp.BD (K)
dr. Ocsyavina is a digestive surgeon who treats various conditions of the digestive system, including stomach disorders, intestinal diseases, gallbladder issues, colorectal cancer, and abdominal tumors. With extensive clinical experience and advanced training in digestive surgery, she is known for being meticulous, communicative, and highly focused on patient safety and comfort.
Clinic hours:
- Monday: 16.00–18.00 WIB
- Tuesday: 16.00–18.00 WIB
- Wednesday: 16.00–18.00 WIB
- Thursday: 16.00–18.00 WIB
- Friday: 16.00–18.00 WIB
- Saturday: 10.00–12.00 WIB
2. dr. Emerson Budiarman Masli, Sp.B, Subsp.BD (K)
dr. Emerson is an experienced digestive surgeon who handles various conditions such as gallstones, appendicitis, hernias, as well as surgical procedures for liver cancer and colon cancer. With precise surgical techniques and a strong emphasis on patient safety, Dr. Emerson is highly recommended in the field.
Clinic hours:
- Monday: 10.00–13.00 WIB
- Wednesday: 10.00–13.00 WIB
3. Prof. Dr. dr. Toar Jean Maurice Lalisang, Sp.B, Subsp.BD (K)
Prof. Toar is a senior digestive surgeon with a strong reputation in the medical community. He has handled numerous complex digestive cases and is recognized as one of Indonesia’s leading experts in liver transplantation.
He is also actively involved in research, publications, and medical education, serving as a mentor to many young surgeons.
Clinic hours:
- Tuesday: 15.30–17.30 WIB
- Thursday: 15.30–17.30 WIB
- Saturday: 11.00–13.00 WIB
If you need a consultation regarding stage 4 colon cancer treatment using CRS-HIPEC, Mandaya Royal Puri Hospital is ready to assist you with an experienced team of digestive surgeons.
To simplify your visit to Mandaya Royal Hospital Puri, you can use the WhatsApp Chat feature, Book Appointment service, or the Care Dokter app—available on Google Play and the App Store—to check queue numbers and access complete hospital information.
