Advanced-stage ovarian cancer is a phase in which cancer cells have grown more aggressively and begun to spread to other parts of the body. At this stage, the cancer may reach the abdominal cavity, affecting surrounding organs. When ovarian cancer has spread to the peritoneum or abdominal cavity, doctors may recommend a more intensive treatment method—one of which is the CRS-HIPEC procedure, a combination of cytoreductive surgery to remove cancer and the administration of heated chemotherapy directly into the abdominal cavity.
Mandaya Royal Puri Hospital offers CRS-HIPEC treatment supported by experienced digestive and oncology specialists. With complete facilities and advanced technology, the hospital provides comprehensive care for patients with advanced-stage ovarian cancer who require specialized therapy.
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What Is CRS-HIPEC for Advanced-Stage Ovarian Cancer Treatment?
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a specialized cancer treatment used for conditions in which cancer has spread to the lining of the abdominal cavity, known as the peritoneum. HIPEC is typically performed together with cytoreductive surgery (CRS), a procedure in which surgeons remove all visible cancer tissue in the peritoneal area.
After surgery, the abdominal cavity is infused with heated chemotherapy to eliminate any microscopic cancer cells that may remain. This combination of surgery and heated chemotherapy—often referred to as HIPEC surgery—can help reduce the risk of recurrence, extend survival, and even offer the possibility of recovery for some patients.
During HIPEC, chemotherapy is heated to approximately 41–43°C. Because it uses warmed medication, the procedure is often referred to as “heated chemotherapy wash.” The heat improves the effectiveness of the drug by helping it penetrate cancerous tissue more efficiently.
Unlike standard chemotherapy that circulates through the bloodstream, HIPEC works directly at the site where the cancer has spread. This allows for a higher concentration of chemotherapy at the tumor location while reducing systemic side effects since the drug is minimally absorbed into the bloodstream.
Benefits of CRS-HIPEC for Advanced-Stage Ovarian Cancer
HIPEC has become an increasingly preferred option because it offers several advantages for cancers that have spread to the peritoneum, including advanced-stage ovarian cancer. Its main benefits include:
- Reaches areas inaccessible to standard chemotherapy, as heated chemotherapy is circulated directly in the abdominal cavity and can target cancer cells in the peritoneal lining.
- More precise in destroying cancer cells, including microscopic cells that cannot be seen during tumor removal surgery.
- Uses high temperatures (around 40–50°C) to enhance the drug’s effectiveness without increasing the risk of systemic side effects.
- Performed in a single operative session, eliminating the need for multiple treatment cycles like conventional chemotherapy.
- Lighter side effects, as the treatment works locally in the abdominal cavity and only a small amount enters the bloodstream.
- Improves treatment success and survival outcomes, especially for patients with advanced-stage cancer that has already spread to the abdominal cavity.
Ovarian Cancer Specialists at Mandaya Royal Puri Hospital
Mandaya Royal Puri Hospital has a team of highly experienced gynecologic oncology specialists who provide expert care for ovarian cancer patients.
1. dr. Ong Tjandra, M.Kes, Sp.OG (K), Subsp. Onk
dr. Ong Tjandra is a consultant obstetrician and gynecologist specializing in oncology who has managed various cancers of the female reproductive system, including ovarian cancer, cervical cancer, endometrial cancer, and benign tumors. He is known for his holistic approach, focusing not only on medical treatment but also on improving patients’ quality of life during and after therapy.
In the HIPEC program at Mandaya Royal Puri Hospital, Dr. Ong plays a key role in conducting comprehensive evaluations to determine the most appropriate treatment plan for patients with advanced-stage ovarian cancer.
Clinic hours:
- Monday: 10.00 – 17.00 WIB
- Thursday: 16.00 – 20.00 WIB
2. Dr. dr. Unedo Hence Markus Sihombing, Sp.OG, Subsp. Onk
Dr. Unedo is a gynecologic oncology consultant experienced in treating ovarian cancer, endometrial cancer, vulvar cancer, as well as benign tumors such as fibroids and ovarian cysts. He is known for his empathetic, communicative, and dedicated approach to patient care.
In the HIPEC procedure, Dr. Unedo participates in surgical treatment for advanced-stage ovarian cancer by combining oncologic surgical expertise with intraperitoneal chemotherapy, allowing for more optimal treatment outcomes.
Clinic hours:
- Tuesday: 16.00 – 20.00 WIB
- Thursday: 16.00 – 20.00 WIB
- Saturday: 13.00 – 16.00 WIB
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