High-Intensity Focused Ultrasound (HIFU) is a non-invasive therapeutic technology used in the treatment of pancreatic cancer by utilizing high-intensity ultrasound waves. This ultrasound energy is precisely focused on the tumor area from outside the body, generating high heat capable of destroying cancer cells (thermal ablation) without the need for incisions or open surgery. Through this mechanism, HIFU can help relieve pain while gradually controlling and reducing tumor size.
HIFU technology for pancreatic cancer is now available at Mandaya Royal Hospital Puri. The treatment is supported by an experienced interventional radiologist, dr. Sugianto Santoso, Sp.Rad, (K)RI, who specializes in image-guided minimally invasive procedures. With modern technology and expert medical support, Mandaya Royal Hospital Puri provides an innovative therapeutic option for pancreatic cancer patients, including those in advanced stages with limited treatment choices.
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Advantages of HIFU in Pancreatic Cancer Treatment
Below are several key advantages of HIFU in treating pancreatic cancer:
1. Does Not Require Open Surgery (Non-Invasive)
HIFU is performed without surgery or body incisions. Since it does not involve open surgical procedures, this therapy tends to cause less physical trauma compared to conventional surgery.
2. Lower Risk and Generally Well Tolerated
Compared to major surgery, HIFU carries relatively lower risks. Most patients can tolerate this therapy well, making it an alternative option for those who are not suitable candidates for invasive procedures.
3. Effective in Relieving Pain
HIFU therapy can significantly reduce pain intensity, including in patients whose pancreatic cancer has metastasized. Pain relief is one of the main benefits, especially in advanced-stage management.
4. Potential to Reduce Tumor Mass
Through thermal ablation, HIFU damages cancer tissue, allowing the tumor to gradually shrink. This reduction can provide additional benefits, particularly when combined with other treatment modalities.
5. Supports Improved Quality of Life
With better pain control and more stable disease conditions, patients may experience an improved quality of life during their treatment journey.
6. Potential Survival Benefit
For patients with limited therapeutic options, HIFU shows potential additional benefits in supporting overall survival. However, further large-scale research is still needed to confirm these findings.
To date, various clinical studies continue to compare standard palliative therapy with a combination of standard therapy and HIFU in advanced pancreatic cancer to further evaluate its overall effectiveness and benefits.
Clinical Research Findings on HIFU Therapy for Pancreatic Cancer
The effectiveness of HIFU in pancreatic cancer treatment is not merely theoretical. In a study titled Clinical Effectiveness and Potential Survival Benefit of US-Guided High-Intensity Focused Ultrasound Therapy in Patients with Advanced-Stage Pancreatic Cancer, this therapy demonstrated promising results in patients with advanced pancreatic cancer.
1. Majority of Patients Experienced Pain Reduction
A total of 84% of 50 advanced-stage pancreatic cancer patients who underwent HIFU therapy reported significant abdominal pain reduction from the early phase of treatment. This pain-relieving effect was maintained throughout the observation period, both in patients with metastasis and those without cancer spread.
2. Gradual Tumor Shrinkage
HIFU also demonstrated measurable impact on tumor size. The average tumor volume decreased by approximately 37.8% within the first 6 weeks after therapy and continued shrinking to around 57.9% within 6 months. These findings indicate that HIFU not only alleviates symptoms but also helps gradually control tumor growth.
3. Indication of Potential Survival Improvement
In the study, the median overall survival was approximately 16.2 months from the time of diagnosis, with a median progression-free survival of around 16.9 months. These results suggest a possible additional survival benefit for advanced pancreatic cancer patients receiving HIFU therapy.
When Can HIFU Be Considered for Pancreatic Cancer?
HIFU therapy may be considered in the following conditions:
- Advanced-stage pancreatic cancer that remains localized around the pancreas and has not spread extensively to distant organs.
- Tumors that are difficult or impossible to remove surgically, for example due to proximity to major blood vessels or when the patient’s condition does not allow major surgery.
- Patients with limited treatment options in advanced stages.
- Patients experiencing severe tumor-related pain, as HIFU can significantly reduce pain.
- Patients requiring tumor size control, as HIFU can gradually shrink tumor mass.
- In certain cases, there may be potential additional benefits in supporting patient survival.
How HIFU Works for Pancreatic Cancer
HIFU works without open surgery by destroying tissue using heat (thermal ablation). Here is a simplified explanation:
- Ultrasound waves are precisely directed to the tumor location under ultrasound (USG) guidance.
- The energy is concentrated at a focal point until the temperature rises above 80°C.
- The heat destroys cancer cells, and the damaged tumor tissue gradually shrinks over weeks to months.
HIFU Specialist for Pancreatic Cancer at Mandaya Royal Hospital Puri
HIFU procedures at Mandaya Royal Hospital Puri are performed by dr. Sugianto Santoso, Sp.Rad, (K)RI, a radiologist with a subspecialty in interventional radiology who is experienced in various minimally invasive procedures.
In his clinical practice, he utilizes imaging guidance such as ultrasound, CT scan, MRI, and fluoroscopy to ensure each procedure is performed accurately and safely. In addition to HIFU, he is also skilled in performing TACE (transarterial chemoembolization), radiofrequency ablation (RFA), and microwave ablation to destroy tumor tissue without major surgery.
He completed his General Medical degree at Universitas Kristen Maranatha, Bandung, and pursued his Radiology Specialist training at Universitas Indonesia. With his educational background and clinical experience, dr. Sugianto contributes to the implementation of modern minimally invasive technologies to support more targeted pancreatic cancer treatment with better-controlled risks.
dr. Sugianto Santoso, Sp.Rad, (K)RI is available at Mandaya Royal Hospital Puri on:
- Tuesday: 16:00 – 20:00 WIB
- Thursday: 16:00 – 20:00 WIB
To make your visit easier, use the Chat feature via WhatsApp, Book Appointment, or the Care Dokter application available on Google Play and the App Store to schedule visits, check queue numbers, and obtain further information.
