Ovarian cancer stage 4 is the most advanced form of the disease, where cancer cells not only grow within the ovarian tissue but have also spread to other organs, including the abdominal cavity. At this stage, cancer spread can lead to fluid buildup in the abdomen, pain, and impaired organ function, requiring a more integrated and comprehensive treatment approach.
RS Mandaya Royal Puri provides CRS-HIPEC therapy, a combination of cytoreductive surgery and heated intraperitoneal chemotherapy that works directly inside the abdominal cavity. This method is designed for treating stage 4 ovarian cancer that has spread extensively, aiming to remove as much visible tumor tissue as possible while simultaneously destroying microscopic cancer cells using high-temperature chemotherapy.
Contents
Understanding CRS-HIPEC Treatment for Stage 4 Ovarian Cancer at Mandaya
CRS-HIPEC is a modern cancer treatment method specifically designed to target tumors located within the peritoneal cavity—the area that lines and protects vital organs such as the liver, stomach, and intestines.
The procedure is performed after the main tumor has been surgically removed, followed by the administration of heated chemotherapy at approximately 40–50°C. The chemotherapy solution is circulated directly within the abdominal cavity to eliminate cancer cells that are invisible to the naked eye. The combination of heat and chemotherapy creates a synergistic effect that enhances treatment effectiveness.
The HIPEC procedure consists of two main stages completed in a single surgical session:
1. Cytoreductive Surgery
In the first step, surgeons remove as much visible tumor tissue as possible from the abdominal cavity. Under general anesthesia, the surgical team examines the entire abdomen and removes affected tissues to reduce the tumor burden. This step is crucial to allow the heated chemotherapy to work optimally in the next phase.
2. Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Once all macroscopic tumor tissue is removed, the procedure continues with HIPEC. Heated chemotherapy is circulated inside the abdominal cavity using a perfusion machine through specialized catheters. The solution is circulated for 1–2 hours to ensure even exposure throughout the area. Afterward, the chemotherapy fluid is drained, the abdomen is rinsed with a sterile solution, and the surgical incision is carefully closed.
Benefits of CRS-HIPEC for Stage 4 Ovarian Cancer Spread to the Abdominal Cavity
HIPEC offers several benefits, making it one of the most effective therapeutic options for cancers that have spread to the peritoneum. Key advantages include:
- Able to reach areas that systemic chemotherapy cannot, as heated chemotherapy is delivered directly into the abdominal cavity and can penetrate the peritoneal lining.
- Greater precision in targeting cancer cells, including microscopic cells that may not be visible during surgery.
- Uses high temperatures (40–50°C) to increase drug effectiveness without adding the side effects typically associated with systemic chemotherapy.
- Performed in a single surgical procedure, reducing the need for multiple cycles like traditional chemotherapy.
- Causes fewer side effects because the drugs work locally within the abdominal cavity and only a small amount enters the bloodstream.
- Improves treatment success rates and survival outcomes, especially for patients with advanced-stage cancer that has already spread to the abdominal cavity.
Ovarian Cancer Specialists at RS Mandaya Royal Puri
1. dr. Ong Tjandra, M.Kes, Sp.OG (K), Subsp. Onk
dr. Ong Tjandra is an obstetrics and gynecology specialist and oncology consultant with extensive experience in treating various cancers of the female reproductive system, including ovarian, cervical, and uterine cancer, as well as benign tumors. He is well-regarded for his holistic approach, focusing not only on medical treatment but also on improving patients’ quality of life after therapy.
As part of the HIPEC team at RS Mandaya Royal Puri, dr. Ong plays a key role in conducting comprehensive evaluations for advanced ovarian cancer patients to ensure the treatment plan is accurate and appropriate.
Clinic hours:
- Monday: 10.00 – 17.00 WIB
- Thursday: 16.00 – 20.00 WIB
2. Dr. dr. Unedo Hence Markus Sihombing, Sp.OG, Subsp. Onk
Dr. Unedo Hence Markus Sihombing is a gynecologic oncology consultant experienced in handling ovarian cancer, endometrial cancer, vulvar cancer, and benign tumors such as myomas and ovarian cysts. He is known for his empathetic approach and strong dedication to patient care.
In the HIPEC procedure, Dr. Unedo contributes to the surgical management of advanced ovarian cancer, combining his expertise in oncologic surgery with intraperitoneal chemotherapy to achieve optimal therapeutic results.
Clinic hours:
- Tuesday: 16.00 – 20.00 WIB
- Thursday: 16.00 – 20.00 WIB
- Saturday: 13.00 – 16.00 WIB
To simplify your visit to Mandaya Royal Hospital Puri, you can use the WhatsApp Chat feature, Book Appointment service, or the Care Dokter app—available on Google Play and the App Store—to check queue numbers and access complete hospital information.
